EMD-41822
Local refinement of Plasmodium falciparum gametocyte surface protein Pfs48/45 Domains 1 and 2 in complex with neutralizing antibodies
EMD-41822
Single-particle3.3 Å
Deposition: 01/09/2023Map released: 12/03/2025
Last modified: 27/08/2025
Sample Organism:
Homo sapiens,
Plasmodium falciparum 3D7
Sample: complex of Pfs48/45, RUPA58 and RUPA154
Fitted models: 8u1p
Deposition Authors: Kucharska I
,
Hailemariam S,
Ivanochko D,
Rubinstein J,
Julien JP
Sample: complex of Pfs48/45, RUPA58 and RUPA154
Fitted models: 8u1p
Deposition Authors: Kucharska I
,
Hailemariam S,
Ivanochko D,
Rubinstein J,
Julien JP
Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual.
Kucharska I ,
Ivanochko D,
Hailemariam S,
Inklaar MR,
Kim HR,
Teelen K,
Stoter R,
van de Vegte-Bolmer M,
van Gemert GJ,
Semesi A,
McLeod B,
Ki A ,
Lee WK ,
Rubinstein JL ,
Jore MM ,
Julien JP
(2025) Nat Struct Mol Biol , 32 , 1396 - 1407
,
Ivanochko D,
Hailemariam S,
Inklaar MR,
Kim HR,
Teelen K,
Stoter R,
van de Vegte-Bolmer M,
van Gemert GJ,
Semesi A,
McLeod B,
Ki A ,
Lee WK ,
Rubinstein JL ,
Jore MM ,
Julien JP
(2025) Nat Struct Mol Biol , 32 , 1396 - 1407
Grant Support:
- CIFAR Azrieli Global Scholars: (Canada)
- Ontario Early Researcher Awards: (Canada)
- Canada Research Chairs: (Canada)
- Canada Foundation for Innovation: (Canada)
- Ontario Research Fund: (Canada)
- Canadian Institutes of Health Research (CIHR): (Canada)
- Other government: Canada Graduate Scholarships Doctoral Award (Canada)
- Netherlands Organisation for Scientific Research (NWO): 192.061 (Netherlands)