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EMD-41766
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant, scFv16, and dopamine
EMD-41766
Single-particle3.2 Å
Deposition: 27/08/2023Map released: 21/08/2024
Last modified: 14/05/2025
Sample Organism:
Homo sapiens,
Escherichia coli
Sample: Human DRD2 in complex with heterotrimeric G protein GoA (K46E), scFv16, and dopamine
Fitted models: 8tzq
Deposition Authors: Krumm BE
,
Kapolka NJ,
Fay JF ,
Roth BL
Sample: Human DRD2 in complex with heterotrimeric G protein GoA (K46E), scFv16, and dopamine
Fitted models: 8tzq
Deposition Authors: Krumm BE
,
Kapolka NJ,
Fay JF ,
Roth BL
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM ,
Krumm BE ,
Kapolka NJ,
Ludlam WG ,
Cui M ,
Mani S ,
Prytkova I,
Obarow EG,
Lefevre TJ ,
Wei W ,
Ma N ,
Huang XP ,
Fay JF ,
Vaidehi N ,
Smrcka AV,
Slesinger PA ,
Logothetis DE ,
Martemyanov KA ,
Roth BL ,
Dohlman HG
(2024) Nat Commun , 15 , 6643 - 6643
,
Krumm BE ,
Kapolka NJ,
Ludlam WG ,
Cui M ,
Mani S ,
Prytkova I,
Obarow EG,
Lefevre TJ ,
Wei W ,
Ma N ,
Huang XP ,
Fay JF ,
Vaidehi N ,
Smrcka AV,
Slesinger PA ,
Logothetis DE ,
Martemyanov KA ,
Roth BL ,
Dohlman HG
(2024) Nat Commun , 15 , 6643 - 6643
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