EMD-41759

Single-particle
3.9 Å
EMD-41759
3D View Gallery
Deposition: 26/08/2023
Map released: 06/12/2023
Last modified: 25/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41759

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8tzh summary report (pdf.gz) Map-8tzh FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant)

EMD-41759

Single-particle
3.9 Å
EMD-41759
3D View Gallery
Deposition: 26/08/2023
Map released: 06/12/2023
Last modified: 25/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Full-length LRRK2 (I2020T mutation) bound to MLi-2
Fitted models: 8tzh

Deposition Authors: Sanz-Murillo M, Villagran-Suarez A, Alegrio Louro J , Leschziner A
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sanz Murillo M , Villagran Suarez A , Dederer V , Chatterjee D, Alegrio Louro J , Knapp S , Mathea S , Leschziner AE
(2023) Sci Adv , 9 , eadk6191 - eadk6191
PUBMED: 38039358
DOI: doi:10.1126/sciadv.adk6191
ISSN: 2375-2548
Grant Support: