EMD-41753

Single-particle
3.1 Å
EMD-41753
3D View Gallery
Deposition: 26/08/2023
Map released: 06/12/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41753

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8tzb summary report (pdf.gz) Map-8tzb FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Structure of the C-terminal half of LRRK2 bound to GZD-824 (I2020T mutant)

EMD-41753

Single-particle
3.1 Å
EMD-41753
3D View Gallery
Deposition: 26/08/2023
Map released: 06/12/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: LRRK2-RCKW G2019S bound to GZD-824 and E11 DARPin
Fitted models: 8tzb

Deposition Authors: Villagran-Suarez A, Sanz-Murillo M, Alegrio-Louro J, Leschziner A
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sanz Murillo M , Villagran Suarez A , Dederer V , Chatterjee D, Alegrio Louro J , Knapp S , Mathea S , Leschziner AE
(2023) Sci Adv , 9 , eadk6191 - eadk6191
PUBMED: 38039358
DOI: doi:10.1126/sciadv.adk6191
ISSN: 2375-2548
Grant Support: