EMD-41728

Single-particle
2.99 Å
EMD-41728
3D View Gallery
Deposition: 25/08/2023
Map released: 06/12/2023
Last modified: 27/12/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41728

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8tyq summary report (pdf.gz) Map-8tyq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Structure of the C-terminal half of LRRK2 bound to GZD-824 (G2019S mutant)

EMD-41728

Single-particle
2.99 Å
EMD-41728
3D View Gallery
Deposition: 25/08/2023
Map released: 06/12/2023
Last modified: 27/12/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: LRRK2-RCKW G2019S bound to GZD-824
Fitted models: 8tyq

Deposition Authors: Villagran-Suarez A, Sanz-Murillo M, Alegrio-Louro J, Leschziner A
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sanz Murillo M , Villagran Suarez A , Dederer V , Chatterjee D, Alegrio Louro J , Knapp S , Mathea S , Leschziner AE
(2023) Sci Adv , 9 , eadk6191 - eadk6191
PUBMED: 38039358
DOI: doi:10.1126/sciadv.adk6191
ISSN: 2375-2548
Grant Support: