EMD-41710

Single-particle
3.46 Å
EMD-41710
3D View Gallery
Deposition: 24/08/2023
Map released: 13/09/2023
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41710

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8ty1 summary report (pdf.gz) Map-8ty1 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of coagulation factor VIII bound to NB2E9

EMD-41710

Single-particle
3.46 Å
EMD-41710
3D View Gallery
Deposition: 24/08/2023
Map released: 13/09/2023
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Coagulation factor VIII bound to NB2E9
Fitted models: 8ty1

Deposition Authors: Childers KC, Spiegel PC
Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain.
Childers KC, Cowper B, Vaughan JD, McGill JR, Davulcu O, Lollar P, Doering CB, Coxon CH, Spiegel Jr PC
(2024) J.Thromb.Haemost. , 22 , 2449 - 2459
PUBMED: 38849084
DOI: doi:10.1016/j.jtha.2024.05.024
ISSN: 1538-7836