Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-41269

Single-particle
3.12 Å
EMD-41269 Deposition: 17/07/2023
Map released: 25/10/2023
Last modified: 08/05/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-41269

Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to Tetrabenazine in an occluded conformation

EMD-41269

Single-particle
3.12 Å
EMD-41269 Deposition: 17/07/2023
Map released: 25/10/2023
Last modified: 08/05/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Vicugna pacos
Sample: Human VMAT2 complexed with Tetrabenazine
Fitted models: 8thr

Deposition Authors: Dalton MP , Coleman JA
Structural mechanisms for VMAT2 inhibition by tetrabenazine.
Dalton MP , Cheng MH , Bahar I, Coleman JA
(2024) eLife , 12
PUBMED: 38517752
DOI: doi:10.7554/eLife.91973
ISSN: 2050-084X
Grant Support: