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EMD-41172
Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, variant-type morphology
EMD-41172
Helical reconstruction3.1 Å
Deposition: 04/07/2023Map released: 13/12/2023
Last modified: 14/05/2025
Sample Organism:
Homo sapiens
Sample: Transthyretin fibrils extracted from patient heart.
Fitted models: 8tdo
Deposition Authors: Nguyen BA
,
Singh V ,
Saelices L
Sample: Transthyretin fibrils extracted from patient heart.
Fitted models: 8tdo
Deposition Authors: Nguyen BA
,
Singh V ,
Saelices L
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.
Nguyen BA ,
Singh V ,
Afrin S,
Yakubovska A,
Wang L,
Ahmed Y,
Pedretti R,
Fernandez-Ramirez MDC,
Singh P ,
Pekala M,
Cabrera Hernandez LO ,
Kumar S,
Lemoff A ,
Gonzalez-Prieto R ,
Sawaya MR ,
Eisenberg DS ,
Benson MD,
Saelices L
(2024) Nat Commun , 15 , 581 - 581
,
Singh V ,
Afrin S,
Yakubovska A,
Wang L,
Ahmed Y,
Pedretti R,
Fernandez-Ramirez MDC,
Singh P ,
Pekala M,
Cabrera Hernandez LO ,
Kumar S,
Lemoff A ,
Gonzalez-Prieto R ,
Sawaya MR ,
Eisenberg DS ,
Benson MD,
Saelices L
(2024) Nat Commun , 15 , 581 - 581
Grant Support:
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): DP2-HL163810 (United States)
- American Heart Association: Career Development Award 847236 (United States)
- Welch Foundation: Research Award I-2121-20220331 (United States)