EMD-41154
Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf
EMD-41154
Single-particle3.4 Å
Deposition: 30/06/2023Map released: 27/09/2023
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Ternary complex of integrin heterodimer (alpha-v beta-6) and the de novo minibinder protein B6_BP_dslf
Fitted models: 8tcg
Deposition Authors: Campbell MG
,
Fernandez A ,
Roy A,
Kraft J,
Baker D
Sample: Ternary complex of integrin heterodimer (alpha-v beta-6) and the de novo minibinder protein B6_BP_dslf
Fitted models: 8tcg
Deposition Authors: Campbell MG
,
Fernandez A ,
Roy A,
Kraft J,
Baker D
De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
Roy A,
Shi L,
Chang A,
Dong X,
Fernandez A ,
Kraft JC ,
Li J,
Le VQ ,
Winegar RV,
Cherf GM,
Slocum D ,
Poulson PD ,
Casper GE,
Vallecillo-Zuniga ML ,
Valdoz JC ,
Miranda MC ,
Bai H,
Kipnis Y ,
Olshefsky A ,
Priya T,
Carter L ,
Ravichandran R,
Chow CM,
Johnson MR,
Cheng S,
Smith M,
Overed-Sayer C,
Finch DK,
Lowe D,
Bera AK ,
Matute-Bello G,
Birkland TP,
DiMaio F,
Raghu G,
Cochran JR ,
Stewart LJ,
Campbell MG ,
Van Ry PM,
Springer T,
Baker D
(2023) Nat Commun , 14 , 5660 - 5660
,
Kraft JC ,
Li J,
Le VQ ,
Winegar RV,
Cherf GM,
Slocum D ,
Poulson PD ,
Casper GE,
Vallecillo-Zuniga ML ,
Valdoz JC ,
Miranda MC ,
Bai H,
Kipnis Y ,
Olshefsky A ,
Priya T,
Carter L ,
Ravichandran R,
Chow CM,
Johnson MR,
Cheng S,
Smith M,
Overed-Sayer C,
Finch DK,
Lowe D,
Bera AK ,
Matute-Bello G,
Birkland TP,
DiMaio F,
Raghu G,
Cochran JR ,
Stewart LJ,
Campbell MG ,
Van Ry PM,
Springer T,
Baker D
(2023) Nat Commun , 14 , 5660 - 5660
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35 GM147414 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01 GM092802 (United States)
- The Pew Charitable Trusts: (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM008268-33 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)