EMD-41145

Single-particle
2.94 Å
EMD-41145
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Deposition: 28/06/2023
Map released: 04/10/2023
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-41145
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8tb7 summary report (pdf.gz) Map and 8tb7 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM Structure of GPR61-

EMD-41145

Single-particle
2.94 Å
EMD-41145
3D View Gallery
Deposition: 28/06/2023
Map released: 04/10/2023
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: GPR61-ICL3-BRIL chimera in complex with anti-BRIL Fab24 BAK5 and hinge-binding nanobody bound to inverse agonist Compound 1
Fitted models: 8tb7

Deposition Authors: Lees JA, Dias JM , Han S
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Lees JA, Dias JM , Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG , Fisher EL , Tuttle JB, Lovett G, Kormos BL , Unwalla RJ, Zhang L, Dechert Schmitt AM, Zhou D, Moran M , Stevens KA, Fennell KF, Varghese AE, Maxwell A, Cote EE, Zhang Y, Han S
(2023) Nat Commun , 14 , 5938 - 5938
PUBMED: 37741852
DOI: doi:10.1038/s41467-023-41646-3
ISSN: 2041-1723