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EMD-41144
Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16
EMD-41144
Single-particle3.47 Å
Deposition: 28/06/2023Map released: 04/10/2023
Last modified: 28/05/2025
Sample Organism:
Homo sapiens
Sample: GPR61-GalphaS-Gbeta1-Ggamma2 complex with single-chain Fv16
Fitted models: 8tb0
Deposition Authors: Lees JA
,
Dias JM ,
Han S
Sample: GPR61-GalphaS-Gbeta1-Ggamma2 complex with single-chain Fv16
Fitted models: 8tb0
Deposition Authors: Lees JA
,
Dias JM ,
Han S
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Lees JA ,
Dias JM ,
Rajamohan F,
Fortin JP,
O'Connor R,
Kong JX,
Hughes EAG ,
Fisher EL ,
Tuttle JB,
Lovett G,
Kormos BL ,
Unwalla RJ,
Zhang L,
Dechert Schmitt AM,
Zhou D,
Moran M ,
Stevens KA,
Fennell KF,
Varghese AE,
Maxwell A,
Cote EE,
Zhang Y,
Han S
(2023) Nat Commun , 14 , 5938 - 5938
,
Dias JM ,
Rajamohan F,
Fortin JP,
O'Connor R,
Kong JX,
Hughes EAG ,
Fisher EL ,
Tuttle JB,
Lovett G,
Kormos BL ,
Unwalla RJ,
Zhang L,
Dechert Schmitt AM,
Zhou D,
Moran M ,
Stevens KA,
Fennell KF,
Varghese AE,
Maxwell A,
Cote EE,
Zhang Y,
Han S
(2023) Nat Commun , 14 , 5938 - 5938
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