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EMD-41142
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
EMD-41142
Single-particle3.5 Å
Deposition: 27/06/2023Map released: 27/09/2023
Last modified: 13/12/2023
Sample Organism:
Homo sapiens
Sample: Anaphase-Promoting Complex/Cyclosome in complex with CDH1, UBE2C, UBE2S, Cyclin-B
Fitted models: 8tau
Deposition Authors: Bodrug T, Welsh KA
,
Bolhuis DL ,
Paulakonis E,
Martinez-Chacin RC,
Liu B,
Pinkin N,
Bonacci T,
Cui L,
Xu P ,
Roscow O,
Amann SJ,
Grishkovskaya I ,
Emanuele MJ ,
Harrison JS ,
Steimel JP,
Hahn KM ,
Zhang W,
Zhong E,
Haselbach D ,
Brown NG
Sample: Anaphase-Promoting Complex/Cyclosome in complex with CDH1, UBE2C, UBE2S, Cyclin-B
Fitted models: 8tau
Deposition Authors: Bodrug T, Welsh KA
,
Bolhuis DL ,
Paulakonis E,
Martinez-Chacin RC,
Liu B,
Pinkin N,
Bonacci T,
Cui L,
Xu P ,
Roscow O,
Amann SJ,
Grishkovskaya I ,
Emanuele MJ ,
Harrison JS ,
Steimel JP,
Hahn KM ,
Zhang W,
Zhong E,
Haselbach D ,
Brown NG
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Bodrug T,
Welsh KA ,
Bolhuis DL ,
Paulakonis E,
Martinez-Chacin RC,
Liu B,
Pinkin N,
Bonacci T,
Cui L,
Xu P ,
Roscow O,
Amann SJ,
Grishkovskaya I ,
Emanuele MJ ,
Harrison JS ,
Steimel JP,
Hahn KM ,
Zhang W,
Zhong ED ,
Haselbach D ,
Brown NG
(2023) Nat Struct Mol Biol , 30 , 1663 - 1674
,
Bolhuis DL ,
Paulakonis E,
Martinez-Chacin RC,
Liu B,
Pinkin N,
Bonacci T,
Cui L,
Xu P ,
Roscow O,
Amann SJ,
Grishkovskaya I ,
Emanuele MJ ,
Harrison JS ,
Steimel JP,
Hahn KM ,
Zhang W,
Zhong ED ,
Haselbach D ,
Brown NG
(2023) Nat Struct Mol Biol , 30 , 1663 - 1674
Grant Support:
- National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD): T32GM008570 (United States)
- Vienna Science and Technology Fund (WWTF): WWTF-LS19-029 (Austria)
- National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD): R35GM128855 (United States)
- National Science Foundation (NSF, United States): DGE-1650116 (United States)