EMD-41126
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42
EMD-41126
Single-particle2.74 Å
Deposition: 26/06/2023Map released: 31/01/2024
Last modified: 28/05/2025
Sample Organism:
Homo sapiens
Sample: Chloride channel protein 2 with inhibitor AK-42
Fitted models: 8ta2
Deposition Authors: Xu M
,
Neelands T,
Powers AS,
Liu Y ,
Miller S,
Pintilie G,
Du Bois J,
Dror RO ,
Chiu W ,
Maduke M
Sample: Chloride channel protein 2 with inhibitor AK-42
Fitted models: 8ta2
Deposition Authors: Xu M
,
Neelands T,
Powers AS,
Liu Y ,
Miller S,
Pintilie G,
Du Bois J,
Dror RO ,
Chiu W ,
Maduke M
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Xu M ,
Neelands T,
Powers AS,
Liu Y ,
Miller SD,
Pintilie GD,
Bois JD,
Dror RO ,
Chiu W ,
Maduke M
(2024) eLife , 12
,
Neelands T,
Powers AS,
Liu Y ,
Miller SD,
Pintilie GD,
Bois JD,
Dror RO ,
Chiu W ,
Maduke M
(2024) eLife , 12
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM079429 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM129541 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NS113611 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NS125767 (United States)