EMD-41048
Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
EMD-41048
Single-particle4.7 Å
Deposition: 13/06/2023Map released: 03/01/2024
Last modified: 20/11/2024
Sample Organism:
Lassa virus Josiah,
Homo sapiens,
Camelus bactrianus
Sample: Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Fitted models: 8t5c
Deposition Authors: Gorman J
,
Kwong PD
Sample: Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Fitted models: 8t5c
Deposition Authors: Gorman J
,
Kwong PD
Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
Gorman J ,
Cheung CS,
Duan Z,
Ou L,
Wang M,
Chen X ,
Cheng C,
Biju A,
Sun Y,
Wang P ,
Yang Y,
Zhang B,
Boyington JC,
Bylund T ,
Charaf S,
Chen SJ,
Du H,
Henry AR,
Liu T,
Sarfo EK ,
Schramm CA ,
Shen CH,
Stephens T,
Teng IT,
Todd JP,
Tsybovsky Y ,
Verardi R ,
Wang D ,
Wang S ,
Wang Z,
Zheng CY,
Zhou T ,
Douek DC ,
Mascola JR,
Ho DD,
Ho M ,
Kwong PD
(2024) Nat Commun , 15 , 285 - 285
,
Cheung CS,
Duan Z,
Ou L,
Wang M,
Chen X ,
Cheng C,
Biju A,
Sun Y,
Wang P ,
Yang Y,
Zhang B,
Boyington JC,
Bylund T ,
Charaf S,
Chen SJ,
Du H,
Henry AR,
Liu T,
Sarfo EK ,
Schramm CA ,
Shen CH,
Stephens T,
Teng IT,
Todd JP,
Tsybovsky Y ,
Verardi R ,
Wang D ,
Wang S ,
Wang Z,
Zheng CY,
Zhou T ,
Douek DC ,
Mascola JR,
Ho DD,
Ho M ,
Kwong PD
(2024) Nat Commun , 15 , 285 - 285
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM103310 (United States)
- Simons Foundation: SF349247 (United States)