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EMD-40750

Single-particle
3.66 Å
EMD-40750
3D View Gallery
Deposition: 08/05/2023
Map released: 06/09/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40750
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8ssb summary report (pdf.gz) Map and 8ssb FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)

EMD-40750

Single-particle
3.66 Å
EMD-40750
3D View Gallery
Deposition: 08/05/2023
Map released: 06/09/2023
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Rattus norvegicus, Homo sapiens
Sample: GluA2-TARP gamma5-cornichon-2
Fitted models: 8ssb

Deposition Authors: Gangwar SP , Yen LY, Yelshanskaya MV, Sobolevsky AI
Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Gangwar SP , Yen LY, Yelshanskaya MV, Korman A , Jones DR , Sobolevsky AI
(2023) Nat Struct Mol Biol , 30 , 1481 - 1494
PUBMED: 37653241
DOI: doi:10.1038/s41594-023-01080-x
ISSN: 1545-9985