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EMD-40729

Composite map
Single-particle
2.52 Å
EMD-40729
3D View Gallery
Deposition: 05/05/2023
Map released: 15/05/2024
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40729
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8srf summary report (pdf.gz) Map and 8srf FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state

EMD-40729

Composite map
Single-particle
2.52 Å
EMD-40729
3D View Gallery
Deposition: 05/05/2023
Map released: 15/05/2024
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Salpingoeca rosetta
Sample: TRPM2 chanzyme incubated with Magnesium and ADP-ribose for 10s; ADP-ribose partially hydrolyzed; intact ADP-ribose in MHR1/2 domain; Adenosine monophosphate and Ribose-5-phosphate in NUDT9-H domain; closed state.
Fitted models: 8srf

Deposition Authors: Huang Y, Kumar S , Lu W , Du J
Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Huang Y, Kumar S , Lee J , Lu W , Du J
(2024) Nat Struct Mol Biol , 31 , 1509 - 1521
PUBMED: 38773335
DOI: doi:10.1038/s41594-024-01316-4
ISSN: 1545-9985