Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-40676
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
EMD-40676
Single-particle2.79 Å
Deposition: 02/05/2023Map released: 23/08/2023
Last modified: 23/08/2023
Sample Organism:
Homo sapiens
Sample: sample 1
Fitted models: 8sp8
Deposition Authors: Neuberger A
,
Yelshanskaya MV,
Nadezhdin KD
,
Sobolevsky AI
Sample: sample 1
Fitted models: 8sp8
Deposition Authors: Neuberger A
,
Yelshanskaya MV,
Nadezhdin KD
,
Sobolevsky AI
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin.
Neuberger A
,
Trofimov YA
,
Yelshanskaya MV,
Khau J
,
Nadezhdin KD
,
Khosrof LS
,
Krylov NA
,
Efremov RG,
Sobolevsky AI
(2023) Nat Commun , 14 , 4630 - 4630
,
Trofimov YA
,
Yelshanskaya MV,
Khau J
,
Nadezhdin KD
,
Khosrof LS
,
Krylov NA
,
Efremov RG,
Sobolevsky AI
(2023) Nat Commun , 14 , 4630 - 4630
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01 CA206573 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS083660 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS107253 (United States)
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS): R01 AR078814 (United States)
- German Research Foundation (DFG): 464295817 (Germany)
