EMD-40631

Single-particle
2.78 Å
EMD-40631
3D View Gallery
Deposition: 27/04/2023
Map released: 29/05/2024
Last modified: 11/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40631

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8sno summary report (pdf.gz) Map-8sno FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2

EMD-40631

Single-particle
2.78 Å
EMD-40631
3D View Gallery
Deposition: 27/04/2023
Map released: 29/05/2024
Last modified: 11/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: mature human ADAM17/iRhom2 sheddase complex, conformation 2
Fitted models: 8sno

Deposition Authors: Zhao H, Dai Y , Wang Y, Lee CH
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals.
Lu F, Zhao H, Dai Y , Wang Y, Lee CH, Freeman M
(2024) Mol Cell , 84 , 2152 - 2165.e5
PUBMED: 38781971
DOI: doi:10.1016/j.molcel.2024.04.025
ISSN: 1097-2765
ASTM: MOCEFL