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EMD-40603

Single-particle
2.74 Å
EMD-40603
3D View Gallery
Deposition: 26/04/2023
Map released: 21/02/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40603
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8smv summary report (pdf.gz) Map and 8smv FULL report (pdf.gz)
EMICSS annotations (xml)

GPR161 Gs heterotrimer

EMD-40603

Single-particle
2.74 Å
EMD-40603
3D View Gallery
Deposition: 26/04/2023
Map released: 21/02/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: GPR161 Gs heterotrimeric complex with Nb35
Fitted models: 8smv

Deposition Authors: Hoppe N, Manglik A , Harrison S
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M , Deshpande I, Suomivuori CM , Palicharla VR, Berry SP , Tschaikner P, Regele D, Covey DF , Stefan E , Marks DS , Reiter JF, Dror RO , Evers AS , Mukhopadhyay S , Manglik A
(2024) Nat Struct Mol Biol , 31 , 667 - 677
PUBMED: 38326651
DOI: doi:10.1038/s41594-024-01223-8
ISSN: 1545-9985