EMD-40456

Single-particle
2.9 Å
EMD-40456
3D View Gallery
Deposition: 12/04/2023
Map released: 24/04/2024
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40456
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8sgi summary report (pdf.gz) Map and 8sgi FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human NCX1 in complex with SEA0400

EMD-40456

Single-particle
2.9 Å
EMD-40456
3D View Gallery
Deposition: 12/04/2023
Map released: 24/04/2024
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: human NCX1-SEA0400 in complex with antibody Fab fragment
Fitted models: 8sgi

Deposition Authors: Xue J , Jiang Y
Structural mechanisms of PIP 2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1.
Xue J , Zeng W, John S , Attiq N, Ottolia M , Jiang Y
(2025) eLife , 14
PUBMED: 40433952
DOI: doi:10.7554/eLife.105396
ISSN: 2050-084X