EMD-40258

Single-particle
4.1 Å
EMD-40258
3D View Gallery
Deposition: 30/03/2023
Map released: 23/04/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40258

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8sa0 summary report (pdf.gz) Map-8sa0 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of P-Glycoprotein in occluded closed state under continuous turnover conditions with verapamil

EMD-40258

Single-particle
4.1 Å
EMD-40258
3D View Gallery
Deposition: 30/03/2023
Map released: 23/04/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: P-Glycoprotein in occluded closed state under continuous turnover conditions with verapamil
Fitted models: 8sa0

Deposition Authors: Culbertson A, Liao M
Cryo-EM of human P-glycoprotein reveals an intermediate occluded conformation during active drug transport.
Culbertson AT, Liao M
(2025) Nat Commun , 16 , 3619 - 3619
PUBMED: 40240353
DOI: doi:10.1038/s41467-025-58561-4
ISSN: 2041-1723