EMD-39843

Single-particle
2.82 Å
EMD-39843
3D View Gallery
Deposition: 21/04/2024
Map released: 29/10/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-39843

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8z8a summary report (pdf.gz) Map-8z8a FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of the Lactate-bound human HCAR1-Gi1 complex

EMD-39843

Single-particle
2.82 Å
EMD-39843
3D View Gallery
Deposition: 21/04/2024
Map released: 29/10/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Cryo-EM structure of the Lactate-bound human HCAR1-Gi1 complex
Fitted models: 8z8a

Deposition Authors: Gao M, Zang S, Zhu Y, Mao C, Zhang Y, Ma X
Structural insights into the activation mechanism of the human metabolite receptor HCAR1.
Gao M, Zang S, Zhu Y, Xi K, Du Y, Cheng S, Miao L, Lu Y, Mao C, Zhang Y, Ma X
(2026) Sci Signal , 19 , eadw1483 - eadw1483
PUBMED: 41493973
DOI: doi:10.1126/scisignal.adw1483
ISSN: 1937-9145
Grant Support: