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EMD-39622
Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
EMD-39622
Single-particle3.26 Å
Deposition: 29/03/2024Map released: 18/09/2024
Last modified: 02/07/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
Fitted models: 8yw4
Deposition Authors: Li WZ, Zhou QT, Cong ZT, Yuan QN, Li WX, Zhao FH, Xu HE
,
Zhao LH,
Yang DH,
Wang MW
Sample: Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
Fitted models: 8yw4
Deposition Authors: Li WZ, Zhou QT, Cong ZT, Yuan QN, Li WX, Zhao FH, Xu HE
,
Zhao LH,
Yang DH,
Wang MW
Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Li W,
Zhou Q ,
Cong Z,
Yuan Q,
Li W,
Zhao F,
Xu HE ,
Zhao LH,
Yang D ,
Wang MW
(2024) Cell Discov , 10 , 77 - 77
,
Cong Z,
Yuan Q,
Li W,
Zhao F,
Xu HE ,
Zhao LH,
Yang D ,
Wang MW
(2024) Cell Discov , 10 , 77 - 77
Grant Support:
- National Natural Science Foundation of China (NSFC): 82273961 (China)
- National Natural Science Foundation of China (NSFC): 82073904 (China)
- National Natural Science Foundation of China (NSFC): 81872915 (China)
- National Natural Science Foundation of China (NSFC): 82273985 (China)
- National Natural Science Foundation of China (NSFC): 82121005 (China)
- National Natural Science Foundation of China (NSFC): 81973373 (China)
- National Natural Science Foundation of China (NSFC): 32200576 (Z.T.C.), 32071203(L.H.Z), 82121005(H.E.X.) and 82204474 (F.H.Z.); National Science and Technology Major (China)