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EMD-39365
Cryo-EM structure of ADGRG2-Gs complex with NTF nanobody
EMD-39365
Single-particle2.9 Å
Deposition: 04/03/2024Map released: 13/08/2025
Last modified: 08/10/2025
Sample Organism:
Spodoptera,
Bos taurus
Sample: Complex of ADGRG2 with nanonody and G protein trimer
Fitted models: 8ykd
Deposition Authors: Huang SM, Sheng-chao G
Sample: Complex of ADGRG2 with nanonody and G protein trimer
Fitted models: 8ykd
Deposition Authors: Huang SM, Sheng-chao G
Development of an allosteric adhesion GPCR nanobody with therapeutic potential.
Zheng Y 
,
Jiang D ,
Lu Y ,
Zhang C ,
Huang SM,
Lin H ,
Zhang D ,
Guo S,
Han J ,
Chen J ,
He Y ,
Zhang M ,
Gao Y ,
Guo Y ,
Wei R ,
Xia M,
Qin Y ,
Liu Z,
Yang F ,
Ge S,
Yi F ,
Yu X ,
Lin H ,
Xiao P ,
Sun JP ,
Feng S
(2025) Nat Chem Biol , 21 , 1519 - 1530
,
Jiang D ,
Lu Y ,
Zhang C ,
Huang SM,
Lin H ,
Zhang D ,
Guo S,
Han J ,
Chen J ,
He Y ,
Zhang M ,
Gao Y ,
Guo Y ,
Wei R ,
Xia M,
Qin Y ,
Liu Z,
Yang F ,
Ge S,
Yi F ,
Yu X ,
Lin H ,
Xiao P ,
Sun JP ,
Feng S
(2025) Nat Chem Biol , 21 , 1519 - 1530
Grant Support: