EMD-39161

Single-particle
2.24 Å
EMD-39161
3D View Gallery
Deposition: 18/02/2024
Map released: 19/03/2025
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-39161
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8yd0 summary report (pdf.gz) Map and 8yd0 FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM structure of M. tuberculosis ClpXP1P2 complex bound to bortezomib

EMD-39161

Single-particle
2.24 Å
EMD-39161
3D View Gallery
Deposition: 18/02/2024
Map released: 19/03/2025
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis
Sample: CryoEM structure of M. tuberculosis ClpXP1P2 complex bound to bortezomib
Fitted models: 8yd0

Deposition Authors: Zhou B, Zhao H, Gao Y, Chen X, Zhang T, He J, Xiong X
Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis
Zhou B, Gao Y, Zhao H, Liu B, Zhang H, Fang C, Yuan H, Wang J, Li Z, Zhao Y, Huang X, Wang X, Oliveira ASF, Spencer J, Mulholland AJ, Burston SG, Hu J, Su N, Chen X, He J, Zhang T, Xiong X
(2025) Nat Commun , 16 , 3466
DOI: doi:10.1038/s41467-025-58410-4
ISSN: 2041-1723