EMD-38847
GluN1b-GluN2D NMDA receptor in complex with competitive antagonist R-CPP and allosteric inhibitor YY-23
EMD-38847
Single-particle4.2 Å
Deposition: 25/01/2024Map released: 22/01/2025
Last modified: 04/02/2026
Sample Organism:
Homo sapiens
Sample: N-methyl-D-aspartate receptors
Fitted models: 8y1v
Deposition Authors: Zhang JL, Zhu SJ, Guo F
Sample: N-methyl-D-aspartate receptors
Fitted models: 8y1v
Deposition Authors: Zhang JL, Zhu SJ, Guo F
An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons.
Zhang J ,
Duan J ,
Li W ,
Wang X,
Ren S,
Ye L ,
Liu F ,
Tian X,
Xie Y ,
Huang Y ,
Sun Y ,
Song N ,
Li T,
Cai X ,
Liu Z ,
Zhou H ,
Huang C ,
Li Y ,
Zhu S ,
Guo F
(2025) Sci Adv , 11 , eadq0444 - eadq0444
,
Duan J ,
Li W ,
Wang X,
Ren S,
Ye L ,
Liu F ,
Tian X,
Xie Y ,
Huang Y ,
Sun Y ,
Song N ,
Li T,
Cai X ,
Liu Z ,
Zhou H ,
Huang C ,
Li Y ,
Zhu S ,
Guo F
(2025) Sci Adv , 11 , eadq0444 - eadq0444
Grant Support:
- National Natural Science Foundation of China (NSFC): 31771115 (China)
- National Natural Science Foundation of China (NSFC): 31671049 (China)
- National Natural Science Foundation of China (NSFC): 81030065 (China)
- Chinese Academy of Sciences: XDB32020000 (China)
- Chinese Academy of Sciences: XDA12040214 (China)
- Chinese Academy of Sciences: XDA12040220 (China)
- National Natural Science Foundation of China (NSFC): 81803828 (China)
- Chinese Academy of Sciences: 2019280 (China)
- National Natural Science Foundation of China (NSFC): 32221003 (China)