EMD-3883

Single-particle
2.9 Å
EMD-3883 Deposition: 24/09/2017
Map released: 24/01/2018
Last modified: 04/08/2021
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-3883

High-resolution cryo-EM structure of the human 80S ribosome - (composite structure)

EMD-3883

Single-particle
2.9 Å
EMD-3883 Deposition: 24/09/2017
Map released: 24/01/2018
Last modified: 04/08/2021
Overview 3D View Sample Experiment Validation Additional data Links
Name: 80S ribosome with ligand HHT and HYG
Summary:
Complex [1]
Name: 80S ribosome with ligand HHT and HYG
Details: Human 80S ribosome with modified nucleotides
Natural source [1]
Organism: Homo sapiens
Molecular weight
Experimental Theoretical Method
4 MDa - -
RNA [5]
Name: 28S ribosomal RNA
Number of copies: 1
Details: Modified nucleotide name present in the sequence Ribose-methylation (OAM; OCM; OGM; OUM) M1A (1-methyladenosine) M6A (6-methyladenosine) 66A (N6,N6-dimethyladenosine) M7A (7-methyladenosine) M3C (3-methylcytidine) E3C (3-ethylcytidine (unknown) A4C (4-acetyl-cytidine) M4C (4-methylcytidine) M5C (5-methylcytidine) PCM (3-propyl-Ribose-methylcytidine) (unknown) M2G (2-methylguanosine) M6G (6-methylguanosine) E6G (6-ethylguanosine) (Unknown) P6G (6-propylguanosine) (Unknown) AGM (7-acetyl-Ribose-methylguanosine) (Unknown) A7G (7-acetylguanosine) (unknown) M7G (7-methylguanosine) E7G (7-ethylguanosine) (Unknown) P7G (7-propylguanosine) (Unknown) MHG (Hyper modification in guanosine) (unknown) OUM (Ribose-METHYLURIDINE) M1U (1-methyluridine) M3U (3-methyluridine) P4U (4-Propyluridine) (Unknown) M5U (5-methyluridine) I4U (4-isopropyluridine) (Unknown) PSU (Pseudouridine) ACP (1-methyl-3-(3-amino-3-carboxypropyl)pseudouridine) 19U (1-methylpseudouridine)
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 1 MDa -
Name: 5S ribosomal RNA
Number of copies: 1
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 38 kDa -
Name: 5.8S ribosomal RNA
Number of copies: 1
Details: OUM (Ribose-METHYLURIDINE)
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 50 kDa -
Name: 18S ribosomal RNA
Number of copies: 1
Details: Modified nucleotide name present in the sequence Ribose-methylation (OAM; OCM; OGM; OUM) M1A (1-methyladenosine) M6A (6-methyladenosine) 66A (N6,N6-dimethyladenosine) M7A (7-methyladenosine) M3C (3-methylcytidine) E3C (3-ethylcytidine (unknown) A4C (4-acetyl-cytidine) M4C (4-methylcytidine) M5C (5-methylcytidine) PCM (3-propyl-Ribose-methylcytidine) (unknown) M2G (2-methylguanosine) M6G (6-methylguanosine) E6G (6-ethylguanosine) (Unknown) P6G (6-propylguanosine) (Unknown) AGM (7-acetyl-Ribose-methylguanosine) (Unknown) A7G (7-acetylguanosine) (unknown) M7G (7-methylguanosine) E7G (7-ethylguanosine) (Unknown) P7G (7-propylguanosine) (Unknown) MHG (Hyper modification in guanosine) (unknown) OUM (Ribose-METHYLURIDINE) M1U (1-methyluridine) M3U (3-methyluridine) P4U (4-Propyluridine) (Unknown) M5U (5-methyluridine) I4U (4-isopropyluridine) (Unknown) PSU (Pseudouridine) ACP (1-methyl-3-(3-amino-3-carboxypropyl)pseudouridine) 19U (1-methylpseudouridine)
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 603 kDa -
Name: Human initiator Met-tRNA-i
Number of copies: 1
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 24 kDa -
Protein [76]
Name: 60S ribosomal protein L8
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 28 kDa -
Name: 60S ribosomal protein L3
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 46 kDa -
Name: 60S ribosomal protein L4
Number of copies: 1
Details: Modified amino acid MLZ (Methyl-lysine)
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 47 kDa -
Name: 60S ribosomal protein L5
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 34 kDa -
Name: 60S ribosomal protein L6
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 32 kDa -
Name: 60S ribosomal protein L7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 29 kDa -
Name: 60S ribosomal protein L7a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 30 kDa -
Name: 60S ribosomal protein L9
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 21 kDa -
Name: 60S ribosomal protein L10-like
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 24 kDa -
Name: 60S ribosomal protein L11
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 20 kDa -
Name: 60S ribosomal protein L13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 24 kDa -
Name: 60S ribosomal protein L14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 23 kDa -
Name: 60S ribosomal protein L15
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 24 kDa -
Name: 60S ribosomal protein L13a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 23 kDa -
Name: 60S ribosomal protein L17
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 21 kDa -
Name: 60S ribosomal protein L18
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 21 kDa -
Name: 60S ribosomal protein L19
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 23 kDa -
Name: 60S ribosomal protein L18a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 20 kDa -
Name: 60S ribosomal protein L21
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 18 kDa -
Name: 60S ribosomal protein L22
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 14 kDa -
Name: 60S ribosomal protein L23
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 14 kDa -
Name: 60S ribosomal protein L24
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 17 kDa -
Name: 60S ribosomal protein L23a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 17 kDa -
Name: 60S ribosomal protein L26
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 17 kDa -
Name: 60S ribosomal protein L27
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 15 kDa -
Name: 60S ribosomal protein L27a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 16 kDa -
Name: 60S ribosomal protein L29
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 17 kDa -
Name: 60S ribosomal protein L30
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 12 kDa -
Name: 60S ribosomal protein L31
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 14 kDa -
Name: 60S ribosomal protein L32
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 15 kDa -
Name: 60S ribosomal protein L35a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 12 kDa -
Name: 60S ribosomal protein L34
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 13 kDa -
Name: 60S ribosomal protein L35
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 14 kDa -
Name: 60S ribosomal protein L36
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 12 kDa -
Name: 60S ribosomal protein L37
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 11 kDa -
Name: 60S ribosomal protein L38
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 8 kDa -
Name: 60S ribosomal protein L39
Number of copies: 1
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 6 kDa -
Name: Ubiquitin-60S ribosomal protein L40
Number of copies: 1
Details: Modified amino acid MLZ (Methyl-lysine)
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 14 kDa -
Name: 60S ribosomal protein L41
Number of copies: 1
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 3 kDa -
Name: 60S ribosomal protein L36a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 12 kDa -
Name: 60S ribosomal protein L37a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 10 kDa -
Name: 60S ribosomal protein L28
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 15 kDa -
Name: 60S ribosomal protein L10a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 24 kDa -
Name: 40S ribosomal protein SA
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 32 kDa -
Name: 40S ribosomal protein S3a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 30 kDa -
Name: 40S ribosomal protein S3
EC number: 4.2.99.18
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 26 kDa -
Name: 40S ribosomal protein S4, X isoform
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 29 kDa -
Name: 40S ribosomal protein S5
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 22 kDa -
Name: 40S ribosomal protein S7
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 22 kDa -
Name: 40S ribosomal protein S8
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 24 kDa -
Name: 40S ribosomal protein S10
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 18 kDa -
Name: 40S ribosomal protein S11
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 18 kDa -
Name: 40S ribosomal protein S15
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 17 kDa -
Name: 40S ribosomal protein S16
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 16 kDa -
Name: 40S ribosomal protein S17
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 15 kDa -
Name: 40S ribosomal protein S18
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 17 kDa -
Name: 40S ribosomal protein S19
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 16 kDa -
Name: 40S ribosomal protein S20
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 13 kDa -
Name: 40S ribosomal protein S21
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 9 kDa -
Name: 40S ribosomal protein S23
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 15 kDa -
Name: 40S ribosomal protein S26
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 13 kDa -
Name: 40S ribosomal protein S28
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 7 kDa -
Name: 40S ribosomal protein S29
Number of copies: 1
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 6 kDa -
Name: Receptor of activated protein C kinase 1
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 35 kDa -
Name: 40S ribosomal protein S2
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 31 kDa -
Name: 40S ribosomal protein S6
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 28 kDa -
Name: 40S ribosomal protein S9
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 22 kDa -
Name: 40S ribosomal protein S12
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 14 kDa -
Name: 40S ribosomal protein S13
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 17 kDa -
Name: 40S ribosomal protein S14
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 16 kDa -
Name: 40S ribosomal protein S15a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 14 kDa -
Name: 40S ribosomal protein S24
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 15 kDa -
Name: 40S ribosomal protein S25
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 13 kDa -
Name: 40S ribosomal protein S27
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 9 kDa -
Name: 40S ribosomal protein S30
Number of copies: 1
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 6 kDa -
Name: Ubiquitin-40S ribosomal protein S27a
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Natural source
Organism: Human
Molecular weight
Experimental Theoretical Method
- 18 kDa -
Ligand [5]
Name: MAGNESIUM ION
HET code: MG
Number of copies: 402
ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 24 Da -
Name: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
HET code: HMT
Number of copies: 1
ChEMBL ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 545 Da -
Name: ZINC ION
HET code: ZN
Number of copies: 8
ChEMBL ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 65 Da -
Name: HYGROMYCIN B
HET code: HYG
Number of copies: 1
Molecular weight
Experimental Theoretical Method
- 527 Da -
Name: water
HET code: HOH
Number of copies: 61
ChEMBL ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 18 Da -