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EMD-38557

Single-particle
3.02 Å
EMD-38557
3D View Gallery
Deposition: 04/01/2024
Map released: 04/12/2024
Last modified: 15/01/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-38557
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8xpo summary report (pdf.gz) Map and 8xpo FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of Lassa virus RdRP elongation complex with the NTP form of compound HNC-1664 bound in the active site

EMD-38557

Single-particle
3.02 Å
EMD-38557
3D View Gallery
Deposition: 04/01/2024
Map released: 04/12/2024
Last modified: 15/01/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct, Lassa virus Josiah
Sample: Lassa virus RdRP elongation complex with the NTP form of compound 13b bound in the active site
Fitted models: 8xpo

Deposition Authors: Jing X, Gong P
An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
Jia X, Jing X, Li M, Gao M, Zhong Y, Li E, Liu Y, Li R, Yao G, Liu Q, Zhou M, Hou Y, An L, Hong Y, Li S , Zhang J, Wang W , Zhang K , Gong P , Chiu S
(2024) Nat Commun , 15 , 10750 - 10750
PUBMED: 39737930
DOI: doi:10.1038/s41467-024-54918-3
ISSN: 2041-1723