EMD-38456

Single-particle
2.93 Å
EMD-38456
3D View Gallery
Deposition: 26/12/2023
Map released: 18/12/2024
Last modified: 05/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-38456

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8xlr summary report (pdf.gz) Map-8xlr FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin

EMD-38456

Single-particle
2.93 Å
EMD-38456
3D View Gallery
Deposition: 26/12/2023
Map released: 18/12/2024
Last modified: 05/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Structure of Tamsulosin- and calcium-bound mTMEM16A chloride channel
Fitted models: 8xlr

Deposition Authors: Li HL, Li SL, Li S
Tamsulosin ameliorates bone loss by inhibiting the release of Cl - through wedging into an allosteric site of TMEM16A.
Li S , Sun W , Li S , Zhu L , Guo S , He J, Li Y , Tian C, Zhao Z, Yu T , Li J, Zhang Y, Hai Y , Wang J, Zheng Y, Wang R, Hu X, Ling S , Li H , Li Y
(2025) PNAS , 122 , e2407493121 - e2407493121
PUBMED: 39739807
DOI: doi:10.1073/pnas.2407493121
ISSN: 1091-6490
ASTM: PNASA6