Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-38422
CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2
EMD-38422
Single-particle3.29 Å
Deposition: 23/12/2023Map released: 04/12/2024
Last modified: 02/07/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus,
synthetic construct,
Severe acute respiratory syndrome coronavirus 2
Sample: CryoEM structure of compound HNC-1644 bound with RdRP-RNA
Fitted models: 8xko
Deposition Authors: Li M, An L, Hong Y, Li S
,
Zhang K ,
Gong Q,
Zhang K ,
Chang C,
Li S ,
Li S
Sample: CryoEM structure of compound HNC-1644 bound with RdRP-RNA
Fitted models: 8xko
Deposition Authors: Li M, An L, Hong Y, Li S
,
Zhang K ,
Gong Q,
Zhang K ,
Chang C,
Li S ,
Li S
An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
Jia X,
Jing X,
Li M,
Gao M,
Zhong Y,
Li E,
Liu Y,
Li R,
Yao G,
Liu Q,
Zhou M,
Hou Y,
An L,
Hong Y,
Li S ,
Zhang J,
Wang W ,
Zhang K ,
Gong P ,
Chiu S
(2024) Nat Commun , 15 , 10750 - 10750
,
Zhang J,
Wang W ,
Zhang K ,
Gong P ,
Chiu S
(2024) Nat Commun , 15 , 10750 - 10750
Grant Support:
- Other government: (China)