Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-38161

Single-particle
2.55 Å
EMD-38161
3D View Gallery
Deposition: 29/11/2023
Map released: 14/08/2024
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-38161
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8x94 summary report (pdf.gz) Map and 8x94 FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of human TRPV1 in complex with antagonist --protein purified without CHS

EMD-38161

Single-particle
2.55 Å
EMD-38161
3D View Gallery
Deposition: 29/11/2023
Map released: 14/08/2024
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: TRPV1
Fitted models: 8x94

Deposition Authors: Fan J , Lei X
Structural basis of TRPV1 inhibition by SAF312 and cholesterol.
Fan J , Ke H, Lei J , Wang J, Tominaga M , Lei X
(2024) Nat Commun , 15 , 6689 - 6689
PUBMED: 39107321
DOI: doi:10.1038/s41467-024-51085-3
ISSN: 2041-1723