EMD-37362

Single-particle
2.7 Å
EMD-37362
3D View Gallery
Deposition: 05/09/2023
Map released: 17/04/2024
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-37362

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8w9a summary report (pdf.gz) Map-8w9a FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site

EMD-37362

Single-particle
2.7 Å
EMD-37362
3D View Gallery
Deposition: 05/09/2023
Map released: 17/04/2024
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site
Fitted models: 8w9a

Deposition Authors: Huang X , Ren X, Zhong W
Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop.
Huang X , Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X
(2024) Structure , 32 , 907 - 917.e7
PUBMED: 38582077
DOI: doi:10.1016/j.str.2024.03.007
ISSN: 0969-2126
ASTM: STRUE6
Grant Support: