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EMD-37110
Cryo-EM structure of human gamma-secretase in complex with MK-0752
EMD-37110
Single-particle2.7 Å
Deposition: 08/08/2023Map released: 14/08/2024
Last modified: 16/07/2025
Sample Organism:
Homo sapiens
Sample: Cryo-EM structure of human gamma-secretase in complex with MK-0752
Fitted models: 8kcu
Deposition Authors: Guo X
,
Li H,
Kai U,
Yan C ,
Lei J ,
Zhou R ,
Shi Y ,
Yan C ,
Lei J ,
Zhou R ,
Shi Y
Sample: Cryo-EM structure of human gamma-secretase in complex with MK-0752
Fitted models: 8kcu
Deposition Authors: Guo X
,
Li H,
Kai U,
Yan C ,
Lei J ,
Zhou R ,
Shi Y ,
Yan C ,
Lei J ,
Zhou R ,
Shi Y
Structural basis of human gamma-secretase inhibition by anticancer clinical compounds.
Guo X ,
Li H,
Lu X ,
Liu H,
U K ,
Yan C ,
Lei J ,
Huang J ,
Zhou R ,
Shi Y
(2025) Nat Struct Mol Biol , 32 , 719 - 728
,
Li H,
Lu X ,
Liu H,
U K ,
Yan C ,
Lei J ,
Huang J ,
Zhou R ,
Shi Y
(2025) Nat Struct Mol Biol , 32 , 719 - 728
Grant Support: