EMD-37109

Single-particle
2.6 Å
EMD-37109
3D View Gallery
Deposition: 08/08/2023
Map released: 14/08/2024
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-37109

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8kct summary report (pdf.gz) Map-8kct FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human gamma-secretase in complex with Nirogacestat

EMD-37109

Single-particle
2.6 Å
EMD-37109
3D View Gallery
Deposition: 08/08/2023
Map released: 14/08/2024
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Fitted models: 8kct

Deposition Authors: Guo X , Li H, Kai U, Yan C , Lei J , Zhou R , Shi Y , Yan C , Lei J , Zhou R , Shi Y
Structural basis of human gamma-secretase inhibition by anticancer clinical compounds.
Guo X , Li H, Lu X , Liu H, U K , Yan C , Lei J , Huang J , Zhou R , Shi Y
(2025) Nat Struct Mol Biol , 32 , 719 - 728
PUBMED: 39653842
DOI: doi:10.1038/s41594-024-01439-8
ISSN: 1545-9985