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EMD-37107

Single-particle
3.0 Å
EMD-37107
3D View Gallery
Deposition: 08/08/2023
Map released: 14/08/2024
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-37107
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8kcp summary report (pdf.gz) Map and 8kcp FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human gamma-secretase in complex with Crenigacestat

EMD-37107

Single-particle
3.0 Å
EMD-37107
3D View Gallery
Deposition: 08/08/2023
Map released: 14/08/2024
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of human gamma-secretase in complex with Crenigacestat
Fitted models: 8kcp

Deposition Authors: Guo X , Li H, Kai U, Yan C , Lei J , Zhou R , Shi Y , Yan C , Lei J , Zhou R , Shi Y
Structural basis of human gamma-secretase inhibition by anticancer clinical compounds.
Guo X , Li H, Lu X , Liu H, U K , Yan C , Lei J , Huang J , Zhou R , Shi Y
(2025) Nat Struct Mol Biol , 32 , 719 - 728
PUBMED: 39653842
DOI: doi:10.1038/s41594-024-01439-8
ISSN: 1545-9985
Grant Support:
  • National Basic Research Program of China (973 Program): 2020YFA0509300 (China)
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