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EMD-36323
Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GLP-1R-Gs complex
EMD-36323
Single-particle2.85 Å
Deposition: 27/05/2023Map released: 06/09/2023
Last modified: 13/11/2024
Sample Organism:
Homo sapiens,
synthetic construct,
Rattus norvegicus,
Bos taurus,
Escherichia coli
Sample: Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GLP-1R-Gs complex
Fitted models: 8jip
Deposition Authors: Yang L, Zhou QT, Dai AT, Zhao FH, Chang RL, Ying TL, Wu BL, Yang DH, Wang MW
,
Cong ZT
Sample: Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GLP-1R-Gs complex
Fitted models: 8jip
Deposition Authors: Yang L, Zhou QT, Dai AT, Zhao FH, Chang RL, Ying TL, Wu BL, Yang DH, Wang MW
,
Cong ZT
Structural analysis of the dual agonism at GLP-1R and GCGR.
Li Y,
Zhou Q ,
Dai A,
Zhao F,
Chang R,
Ying T,
Wu B,
Yang D ,
Wang MW ,
Cong Z
(2023) PNAS , 120 , e2303696120 - e2303696120
,
Dai A,
Zhao F,
Chang R,
Ying T,
Wu B,
Yang D ,
Wang MW ,
Cong Z
(2023) PNAS , 120 , e2303696120 - e2303696120
Grant Support:
- National Natural Science Foundation of China (NSFC): 81872915 (China)
- National Natural Science Foundation of China (NSFC): 82073904 (China)
- National Natural Science Foundation of China (NSFC): 82273961 (China)
- National Natural Science Foundation of China (NSFC): 32200576 (China)
- National Natural Science Foundation of China (NSFC): 82273985 (China)
- National Natural Science Foundation of China (NSFC): 82121005 (China)
- National Natural Science Foundation of China (NSFC): 81973373 (China)
- National Natural Science Foundation of China (NSFC): 21704064 (China)