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EMD-36318
Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex
EMD-36318
Single-particle2.98 Å
Deposition: 26/05/2023Map released: 06/09/2023
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
Mus musculus
Sample: HCA2 in complex with Gi heterotrimer
Fitted models: 8jim
Deposition Authors: Zhao C
,
Tian XW,
Liu Y,
Cheng L,
Yan W,
Shao ZH
Sample: HCA2 in complex with Gi heterotrimer
Fitted models: 8jim
Deposition Authors: Zhao C
,
Tian XW,
Liu Y,
Cheng L,
Yan W,
Shao ZH
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Zhao C ,
Wang H,
Liu Y,
Cheng L,
Wang B,
Tian X,
Fu H,
Wu C,
Li Z,
Shen C,
Yu J,
Yang S,
Hu H,
Fu P,
Ma L ,
Wang C,
Yan W,
Shao Z
(2023) Mol Cell , 83 , 3171
,
Wang H,
Liu Y,
Cheng L,
Wang B,
Tian X,
Fu H,
Wu C,
Li Z,
Shen C,
Yu J,
Yang S,
Hu H,
Fu P,
Ma L ,
Wang C,
Yan W,
Shao Z
(2023) Mol Cell , 83 , 3171
Grant Support: