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EMD-35972
CryoEM Structure of 40-Residue Arctic (E22G) Beta-Amyloid Fibril Derived by Co-Analysis with Solid-State NMR | E22G Abeta40
EMD-35972
Helical reconstruction2.5 Å
Deposition: 19/04/2023Map released: 11/09/2024
Last modified: 18/09/2024
Sample Organism:
Homo sapiens
Sample: Amyloid Fibril of 40-Residue Beta-Amyloid with Arctic (E22G) mutation
Fitted models: 8j47
Deposition Authors: Tehrani MJ
,
Matsuda I ,
Yamagata A ,
Matsunaga T,
Sato M ,
Toyooka K ,
Shirouzu M ,
Ishii Y ,
Kodama Y ,
McElheny D,
Kobayashi N
Sample: Amyloid Fibril of 40-Residue Beta-Amyloid with Arctic (E22G) mutation
Fitted models: 8j47
Deposition Authors: Tehrani MJ
,
Matsuda I ,
Yamagata A ,
Matsunaga T,
Sato M ,
Toyooka K ,
Shirouzu M ,
Ishii Y ,
Kodama Y ,
McElheny D,
Kobayashi N
E22G A beta 40 fibril structure and kinetics illuminate how A beta 40 rather than A beta 42 triggers familial Alzheimer's.
Tehrani MJ ,
Matsuda I ,
Yamagata A ,
Kodama Y ,
Matsunaga T,
Sato M ,
Toyooka K ,
McElheny D,
Kobayashi N,
Shirouzu M ,
Ishii Y
(2024) Nat Commun , 15 , 7045 - 7045
,
Matsuda I ,
Yamagata A ,
Kodama Y ,
Matsunaga T,
Sato M ,
Toyooka K ,
McElheny D,
Kobayashi N,
Shirouzu M ,
Ishii Y
(2024) Nat Commun , 15 , 7045 - 7045
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): 5U01GM098033 (United States)
- Japan Science and Technology: JPMJMI17A2, Japan (Japan)
- Japan Society for the Promotion of Science (JSPS): JP22K18328, Japan (Japan)
- Japan Society for the Promotion of Science (JSPS): JP21H05733 (Japan)