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EMD-34951
Activation mechanism of GPR132 by 9(S)-HODE
EMD-34951
Single-particle3.0 Å
Deposition: 13/12/2022Map released: 11/10/2023
Last modified: 23/07/2025
Sample Organism:
Homo sapiens,
Mus musculus
Sample: Cryo-EM structure of the 9(S)HODE-GPR132-Gi complex
Fitted models: 8hqn
Deposition Authors: Wang JL, Ding JH, Sun JP
,
Yu X
Sample: Cryo-EM structure of the 9(S)HODE-GPR132-Gi complex
Fitted models: 8hqn
Deposition Authors: Wang JL, Ding JH, Sun JP
,
Yu X
Functional screening and rational design of compounds targeting GPR132 to treat diabetes.
Wang JL,
Dou XD ,
Cheng J ,
Gao MX,
Xu GF,
Ding W ,
Ding JH,
Li Y ,
Wang SH,
Ji ZW,
Zhao XY,
Huo TY,
Zhang CF,
Liu YM,
Sha XY,
Gao JR,
Zhang WH,
Hao Y ,
Zhang C,
Sun JP ,
Jiao N ,
Yu X
(2023) Nat Metab , 5 , 1726 - 1746
,
Cheng J ,
Gao MX,
Xu GF,
Ding W ,
Ding JH,
Li Y ,
Wang SH,
Ji ZW,
Zhao XY,
Huo TY,
Zhang CF,
Liu YM,
Sha XY,
Gao JR,
Zhang WH,
Hao Y ,
Zhang C,
Sun JP ,
Jiao N ,
Yu X
(2023) Nat Metab , 5 , 1726 - 1746
Grant Support: