EMD-34871
Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
EMD-34871
Single-particle3.63 Å
Deposition: 29/11/2022Map released: 04/10/2023
Last modified: 16/10/2024
Sample Organism:
Homo sapiens,
Escherichia coli (strain K12)
Sample: Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Fitted models: 8hlb
Deposition Authors: Akiba H
,
Fujita J ,
Ise T ,
Nishiyama K ,
Miyata T ,
Kato T ,
Namba K ,
Ohno H ,
Kamada H ,
Nagata S ,
Tsumoto K
Sample: Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Fitted models: 8hlb
Deposition Authors: Akiba H
,
Fujita J ,
Ise T ,
Nishiyama K ,
Miyata T ,
Kato T ,
Namba K ,
Ohno H ,
Kamada H ,
Nagata S ,
Tsumoto K
Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection.
Akiba H ,
Fujita J ,
Ise T ,
Nishiyama K ,
Miyata T ,
Kato T ,
Namba K ,
Ohno H ,
Kamada H ,
Nagata S ,
Tsumoto K
(2023) Commun Biol , 6 , 987 - 987
,
Fujita J ,
Ise T ,
Nishiyama K ,
Miyata T ,
Kato T ,
Namba K ,
Ohno H ,
Kamada H ,
Nagata S ,
Tsumoto K
(2023) Commun Biol , 6 , 987 - 987
Grant Support:
- Japan Agency for Medical Research and Development (AMED): JP22ak0101099 (Japan)
- Japan Agency for Medical Research and Development (AMED): JP21am0101117 (Japan)
- Japan Agency for Medical Research and Development (AMED): JP22ama121003 (Japan)
- Japan Agency for Medical Research and Development (AMED): JP17pc0101020 (Japan)
- Japan Science and Technology: JPMJOP1861 (Japan)
- Japan Society for the Promotion of Science (JSPS): JP21K06453 (Japan)
- Japan Society for the Promotion of Science (JSPS): JP20K22630
- Kyoto University Foundation: (Japan)
- Takeda Science Foundation: (Japan)
- JEOL YOKOGUSHI Research Alliance Laboratories of Osaka University: (Japan)