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EMD-34273

Single-particle
2.62 Å
EMD-34273 Deposition: 11/09/2022
Map released: 23/11/2022
Last modified: 23/11/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-34273

Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719

EMD-34273

Single-particle
2.62 Å
EMD-34273 Deposition: 11/09/2022
Map released: 23/11/2022
Last modified: 23/11/2022
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of PI3Kalpha mutant E545K in complex with BYL-719
Fitted models: 8gud ()

Deposition Authors: Liu X, Zhou Q , Hart JR, Xu Y, Yang S, Yang D , Vogt PK , Wang M-W
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha.
Liu X, Zhou Q , Hart JR, Xu Y, Yang S, Yang D , Vogt PK , Wang MW
(2022) PNAS , 119 , e2215621119 - e2215621119
PUBMED: 36343266
DOI: doi:10.1073/pnas.2215621119
ISSN: 1091-6490
ASTM: PNASA6