EMD-34272

Single-particle
2.73 Å
EMD-34272
3D View Gallery
Deposition: 11/09/2022
Map released: 23/11/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-34272

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8gub summary report (pdf.gz) Map-8gub FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719

EMD-34272

Single-particle
2.73 Å
EMD-34272
3D View Gallery
Deposition: 11/09/2022
Map released: 23/11/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human PI3Kalpha mutant H1047R in complex with BYL-719
Fitted models: 8gub

Deposition Authors: Liu X, Zhou Q , Hart JR , Xu Y, Yang S, Yang D , Vogt PK , Wang M-W
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha.
Liu X, Zhou Q , Hart JR , Xu Y, Yang S, Yang D , Vogt PK , Wang MW
(2022) PNAS , 119 , e2215621119 - e2215621119
PUBMED: 36343266
DOI: doi:10.1073/pnas.2215621119
ISSN: 1091-6490
ASTM: PNASA6