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EMD-34271

Single-particle
2.77 Å
EMD-34271
3D View Gallery
Deposition: 11/09/2022
Map released: 07/12/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-34271
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8gua summary report (pdf.gz) Map and 8gua FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719

EMD-34271

Single-particle
2.77 Å
EMD-34271
3D View Gallery
Deposition: 11/09/2022
Map released: 07/12/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human PI3Kalpha mutant E542K in complex with BYL-719
Fitted models: 8gua

Deposition Authors: Liu X, Zhou Q , Hart JR , Xu Y, Yang S, Yang D , Vogt PK , Wang M-W
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha.
Liu X, Zhou Q , Hart JR , Xu Y, Yang S, Yang D , Vogt PK , Wang MW
(2022) PNAS , 119 , e2215621119 - e2215621119
PUBMED: 36343266
DOI: doi:10.1073/pnas.2215621119
ISSN: 1091-6490
ASTM: PNASA6