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EMD-33699
Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement)
EMD-33699
Single-particle3.11 Å
Deposition: 27/06/2022Map released: 31/08/2022
Last modified: 25/06/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Homo sapiens
Sample: Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement)
Fitted models: 7ya1
Deposition Authors: Zhao ZN, Xie YF, Qi JX, Gao GF
Sample: Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement)
Fitted models: 7ya1
Deposition Authors: Zhao ZN, Xie YF, Qi JX, Gao GF
Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Zhao Z ,
Zhou J,
Tian M,
Huang M,
Liu S,
Xie Y ,
Han P,
Bai C ,
Han P,
Zheng A,
Fu L,
Gao Y,
Peng Q,
Li Y,
Chai Y,
Zhang Z,
Zhao X ,
Song H ,
Qi J ,
Wang Q ,
Wang P ,
Gao GF
(2022) Nat Commun , 13 , 4958 - 4958
,
Zhou J,
Tian M,
Huang M,
Liu S,
Xie Y ,
Han P,
Bai C ,
Han P,
Zheng A,
Fu L,
Gao Y,
Peng Q,
Li Y,
Chai Y,
Zhang Z,
Zhao X ,
Song H ,
Qi J ,
Wang Q ,
Wang P ,
Gao GF
(2022) Nat Commun , 13 , 4958 - 4958
Grant Support:
- Chinese Academy of Sciences: (China)