EMD-33628

Single-particle
3.0 Å
EMD-33628
3D View Gallery
Deposition: 17/06/2022
Map released: 02/11/2022
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-33628

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7y5x summary report (pdf.gz) Map-7y5x FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of PS2-containing gamma-secretase treated with MRK-560

EMD-33628

Single-particle
3.0 Å
EMD-33628
3D View Gallery
Deposition: 17/06/2022
Map released: 02/11/2022
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: PS2-containing gamma-secretase complex treated with MRK-560
Fitted models: 7y5x

Deposition Authors: Guo X , Wang Y , Zhou J, Jin C, Wang J, Jia B , Jing D, Yan C, Lei J , Zhou R , Shi Y
Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Guo X , Wang Y , Zhou J, Jin C, Wang J, Jia B , Jing D, Yan C, Lei J , Zhou R , Shi Y
(2022) Nat Commun , 13 , 6299 - 6299
PUBMED: 36272978
DOI: doi:10.1038/s41467-022-33817-5
ISSN: 2041-1723