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EMD-33453
Structure of SARS-CoV-2 Spike Protein with Engineered x3 Disulfide (x3(D427C, V987C) and single Arg S1/S2 cleavage site), Locked-1 Conformation
EMD-33453
Single-particle2.8 Å
Deposition: 18/05/2022Map released: 20/07/2022
Last modified: 25/06/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus 2
Sample: Severe acute respiratory syndrome coronavirus 2 Spike protein
Fitted models: 7xtz
Deposition Authors: Qu K
,
Chen Q,
Ciazynska KA ,
Liu B,
Zhang X,
Wang J,
He Y,
Guan J,
He J,
Liu T,
Zhang X,
Carter AP ,
Xiong X ,
Briggs JAG
Sample: Severe acute respiratory syndrome coronavirus 2 Spike protein
Fitted models: 7xtz
Deposition Authors: Qu K
,
Chen Q,
Ciazynska KA ,
Liu B,
Zhang X,
Wang J,
He Y,
Guan J,
He J,
Liu T,
Zhang X,
Carter AP ,
Xiong X ,
Briggs JAG
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike.
Qu K ,
Chen Q,
Ciazynska KA ,
Liu B,
Zhang X,
Wang J,
He Y,
Guan J,
He J,
Liu T,
Zhang X,
Carter AP ,
Xiong X ,
Briggs JAG
(2022) PLoS Pathog , 18 , e1010583 - e1010583
,
Chen Q,
Ciazynska KA ,
Liu B,
Zhang X,
Wang J,
He Y,
Guan J,
He J,
Liu T,
Zhang X,
Carter AP ,
Xiong X ,
Briggs JAG
(2022) PLoS Pathog , 18 , e1010583 - e1010583
Grant Support:
- European Research Council (ERC): ERC-CoG-648432 (European Union)
- Medical Research Council (MRC, United Kingdom): MC_UP_A025_1011 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_UP_1201/16 (United Kingdom)