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EMD-33200

Single-particle
2.52 Å
EMD-33200
3D View Gallery
Deposition: 12/04/2022
Map released: 30/11/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-33200
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7xi9 summary report (pdf.gz) Map and 7xi9 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form)

EMD-33200

Single-particle
2.52 Å
EMD-33200
3D View Gallery
Deposition: 12/04/2022
Map released: 30/11/2022
Last modified: 03/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: DNMT1:H3Ub2:DNAmCG/fCGTernary complex of DNMT1 with hemi methylated DNA analog and H3Ub2
Fitted models: 7xi9

Deposition Authors: Onoda H , Kikuchi A , Kori S, Yoshimi S, Yamagata A , Arita K
Structural basis for activation of DNMT1.
Kikuchi A , Onoda H , Yamaguchi K , Kori S, Matsuzawa S, Chiba Y , Tanimoto S, Yoshimi S, Sato H, Yamagata A , Shirouzu M , Adachi N , Sharif J , Koseki H , Nishiyama A , Nakanishi M, Defossez PA , Arita K
(2022) Nat Commun , 13 , 7130 - 7130
PUBMED: 36414620
DOI: doi:10.1038/s41467-022-34779-4
ISSN: 2041-1723