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EMD-33127
Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex
EMD-33127
Single-particle2.72 Å
Deposition: 25/03/2022Map released: 20/04/2022
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Complex of Dot1L(1-416) and H2BK34ub 2:1 nucleosome
Fitted models: 7xct
Deposition Authors: Ai HS, Liu AJ, Lou ZY, Liu L
Sample: Complex of Dot1L(1-416) and H2BK34ub 2:1 nucleosome
Fitted models: 7xct
Deposition Authors: Ai HS, Liu AJ, Lou ZY, Liu L
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.
Ai H ,
Sun M ,
Liu A,
Sun Z,
Liu T,
Cao L,
Liang L,
Qu Q,
Li Z,
Deng Z,
Tong Z,
Chu G,
Tian X,
Deng H ,
Zhao S ,
Li JB ,
Lou Z ,
Liu L
(2022) Nat Chem Biol , 18 , 972 - 980
,
Sun M ,
Liu A,
Sun Z,
Liu T,
Cao L,
Liang L,
Qu Q,
Li Z,
Deng Z,
Tong Z,
Chu G,
Tian X,
Deng H ,
Zhao S ,
Li JB ,
Lou Z ,
Liu L
(2022) Nat Chem Biol , 18 , 972 - 980
Grant Support:
- Other private: 2017YFA0505200 (China)
- National Natural Science Foundation of China (NSFC): 21977090 (China)
- National Natural Science Foundation of China (NSFC): 21532004 (China)
- National Natural Science Foundation of China (NSFC): 91753205 (China)
- National Natural Science Foundation of China (NSFC): 81621002 (China)