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EMD-33058
Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex
EMD-33058
Single-particle3.09 Å
Deposition: 14/03/2022Map released: 29/06/2022
Last modified: 16/10/2024
Sample Organism:
Homo sapiens,
Bos taurus,
Rattus norvegicus,
synthetic construct
Sample: Cryo-EM structure of the human glucagon like peptide 1 receptor in complex with WB4-24 and G protein
Fitted models: 7x8s
Deposition Authors: Cong ZT, Zhou QT, Li Y, Chen LN, Zhang ZC, Liang AY, Liu Q
,
Wu XY,
Dai AT,
Xia T,
Wu W,
Zhang Y ,
Yang DH,
Wang MW
Sample: Cryo-EM structure of the human glucagon like peptide 1 receptor in complex with WB4-24 and G protein
Fitted models: 7x8s
Deposition Authors: Cong ZT, Zhou QT, Li Y, Chen LN, Zhang ZC, Liang AY, Liu Q
,
Wu XY,
Dai AT,
Xia T,
Wu W,
Zhang Y ,
Yang DH,
Wang MW
Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.
Cong Z,
Zhou Q ,
Li Y,
Chen LN,
Zhang ZC,
Liang A,
Liu Q ,
Wu X,
Dai A,
Xia T,
Wu W,
Zhang Y ,
Yang D ,
Wang MW
(2022) PNAS , 119 , e2200155119 - e2200155119
,
Li Y,
Chen LN,
Zhang ZC,
Liang A,
Liu Q ,
Wu X,
Dai A,
Xia T,
Wu W,
Zhang Y ,
Yang D ,
Wang MW
(2022) PNAS , 119 , e2200155119 - e2200155119
Grant Support:
- National Natural Science Foundation of China (NSFC): 81872915 (China)
- National Natural Science Foundation of China (NSFC): 82073904 (China)
- National Natural Science Foundation of China (NSFC): 82121005 (China)
- National Natural Science Foundation of China (NSFC): 81973373 (China)
- National Natural Science Foundation of China (NSFC): 21704064 (China)