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EMD-32331

Single-particle
3.47 Å
EMD-32331
3D View Gallery
Deposition: 02/12/2021
Map released: 28/09/2022
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-32331
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7w6p summary report (pdf.gz) Map and 7w6p FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist

EMD-32331

Single-particle
3.47 Å
EMD-32331
3D View Gallery
Deposition: 02/12/2021
Map released: 28/09/2022
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Signaling complex of alpha2A adrenergic receptor with GoA
Fitted models: 7w6p

Deposition Authors: Xu J , Fink EA , Shoichet BK , Du Y
Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor.
Fink EA , Xu J , Hubner H , Braz JM , Seemann P , Avet C, Craik V , Weikert D , Schmidt MF , Webb CM, Tolmachova NA, Moroz YS, Huang XP , Kalyanaraman C , Gahbauer S , Chen G, Liu Z , Jacobson MP , Irwin JJ , Bouvier M , Du Y , Shoichet BK , Basbaum AI , Gmeiner P
(2022) Science , 377 , eabn7065 - eabn7065
PUBMED: 36173843
DOI: doi:10.1126/science.abn7065
ISSN: 1095-9203
ASTM: SCIEAS